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BMT as initial treatment for severe aplastic anemia, macrophage metabolic rewiring in sickle cell disease, and predicting outcomes using PET radiomics in diffuse large B cell lymphoma

Blood Podcast

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Macrophage Function and Eparocytosis in SCD

Chronic inflammation mediated by heme-activated pro-inflammatory macrophages is a hallmark of sickle cell disease. In SCD, macrophages are stressed due to the shortened half-life of red blood cells and chronic exposure to excess heme because of saturation of haptoglobin and heme-opexin binding capacity. The defects in epharocytosis contribute to tissue damage and sustained inflammation.

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