Organoid Transplantation in Mice

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The colon is part of the large intestine, and it has some differences from the small intestine. It lacks villi, small finger like structures that can help absorb nutrients in the small intestine. But crucially for tashero, the colon does have some key similarities to the small intestine. There both tube structures in the gut. So he wondered if he could use the colon, almost like a scaffold to put the small intestine organoids on so they would grow like a fully fledged organ. He tried this out in mice by first removing the outer surface of the colon and replacing it with the organoid tissue. After the transplantation of humo m organide, the mas colon st

The surprising structure of protons, and a method for growing small intestines for transplantation.

In this episode:

00:45 Probing the proton’s interior

Although studied for decades, the internal structure of the proton is still throwing up surprises for physicists. This week, a team of researchers report an unexpected imbalance in the antimatter particles that make up the proton.

Research Article: Dove et al.

News and Views: Antimatter in the proton is more down than up

07:08 Research Highlights

How an inactive gene may help keep off the chill, and Cuba’s isolation may have prevented invasive species taking root on the island.

Research Highlight: Impervious to cold? A gene helps people to ward off the chills

Research Highlight: Marauding plants steer clear of a communist-ruled island

09:48 A new way to grow a small intestine

Short Bowel Syndrome is an often fatal condition that results from the removal of the small intestine. Treatment options are limited to transplantation, but donor intestines are hard to come by and can be rejected by the body. Now researchers may have developed a method to grow a replacement small intestine using stem cells and a small section of colon.

Research Article: Sugimoto et al.

15:50 Briefing Chat

We discuss some highlights from the Nature Briefing. This time, the landing of Perseverance on Mars, and the researchers speaking with lucid dreamers.

Nature News: Mars video reveals Perseverance rover’s daring touchdown

Nature News: Touch down! NASA’s Mars landing sparks new era of exploration

Nature News: The hunt for life on Mars: A visual guide to NASA’s latest mission

Science: Scientists entered people’s dreams and got them ‘talking’

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