Exploring recent scientific advancements in microdosing and supplement stacking, the chapter discusses studies on the effects of microdosing psychedelics and the motivations behind individuals participating in such research. It delves into the benefits of microdosing in improving mood, cognitive skills, and relieving depression and anxiety. The conversation also touches on specific supplement stacks, the influence of placebo effect in medical treatments, and the potential benefits of Lion's Mane mushroom on cognitive performance.