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Immune 63: Immune, promptly
Immune
Is There a Shift in Inflammation?
There are some non radioactive cytotoxicity assays one can do as well. But it does go back to when you're designing a clinical trial, it isn't the case that those assays are done as frequently because they're not as easy. I have the feeling that there is a shift happening in the way inflammation is discussed. In the last years, the focus seemed to have been on detrimental effects of unregulated inflammation,. Now I read more and more research highlighting the positive role of inflammation, for example, in tissue remodeling and regeneration.
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Speaker 2
I guess you would have to do well in the old days, they used to do cytotoxic assays, right? They used to do chromium release, remember that?
Speaker 3
I do. I have many nightmares about chromium. Yeah, but what you can you can also do things like re simulating the cells in vitro and then looking at cytokine production or degranulation or other types of things to get at that. There are also some non radioactive cytotoxicity assays one can do as well. But it
Speaker 4
does go back to when you're designing a clinical trial, it
Speaker 2
isn't
Speaker 4
the case that those assays are done as frequently because they're not as easy. Yeah, correct.
Speaker 3
Yeah, it's almost like immunity isn't just one thing. I would
Speaker 2
agree. Yeah. Well, that's the theme, right? All right, so we got through that. We have a little time for letters and Steph, you're excited to do a letter. I want you to
Speaker 4
take that first one. Okay, let me go. Okay, Nicholas, that's who I'm on. Yeah. We're Dear Munhose. I thoroughly enjoyed the discussion about the cell host micro paper regarding improved wound healing through IL-1B signaling. That's episode 57. I have the feeling that there is a shift happening in the way inflammation is discussed. Well, in the last years, the focus seemed to have been on detrimental effects of unregulated inflammation, cancer, cytokine storm. Now I
Speaker 1
read more and more research highlighting the positive role of inflammation, for example, in tissue remodeling and
Speaker 4
regeneration.
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