At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives - while supporting medical research into breakthroughs to improve all lives.

We’re building the world’s largest longevity community: Join us at https://lifespan.com.

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In this second installment of Lifespan's two-part series on calorie restriction and fasting, Dr. David Sinclair, A.O., Ph.D. – Professor of Genetics at Harvard Medical School and a pioneer in longevity research – explores how to fast effectively for health and longevity.

Drawing on decades of research and the latest scientific evidence, Dr. Sinclair explains how to approach fasting effectively, what happens inside your body at the 12-, 24-, and 48+-hour marks, how to overcome common plateaus, and the key considerations for women, men, and people at different stages of life.

Whether you're new to fasting or looking to refine your approach, this episode provides a practical, evidence-based guide to using fasting to support metabolism, cellular repair, and healthy longevity.

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Partners of the Lifespan show help us keep this program freely available as an educational resource while also supporting medical research. We only collaborate with partners whose products are grounded in science and that our team has personally used for years.

Our selected partners make it convenient for the Lifespan audience to access the tools and technologies featured in this episode - from exogenous fuel for neurons (Ketone-IQ), to wearables that track recovery, strain, and sleep (WHOOP), to smart devices that measure key health metrics such as visceral fat and muscle mass (Withings).

If you’d like to learn more or try these tools:

○ Ketone-IQ: Get 30% off your first monthly order at https://ketone.com/lifespan or with code LIFESPAN

○ WHOOP: Get a free WHOOP band and one month of membership at https://join.whoop.com/LIFESPAN or with code LIFESPAN

○ Withings: Get 10% off smart health devices at https://withings.com/LIFESPAN

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Legal & Medical Disclaimers

The Lifespan show and all related content are provided for informational and educational purposes only and are not intended as medical advice, diagnosis, or treatment. Nothing presented should be interpreted as a recommendation to diagnose, treat, cure, or prevent any disease or medical condition. This content is not a substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider.

You should always consult with a licensed physician or other qualified healthcare professional before making decisions about your health, including starting, stopping, or modifying any treatment, supplement, diet, or exercise program.

The information shared reflects the views and opinions of the host and guests and is based on the scientific literature, their experience and expertise, and general wellness principles. Listening to or engaging with Lifespan content does not establish a doctor–patient or clinical relationship.

Health and longevity outcomes can vary significantly between individuals. Any references to studies, interventions, products, or protocols are not guarantees of specific results, and individual responses may differ.

From time to time, Lifespan may discuss or partner with third-party products or services. These references are provided for informational purposes only and should not be considered medical recommendations or endorsements of efficacy for any individual.

Lifespan Foundation is an independent 501(c)(3) non-profit organization whose mission is to support medical research.

The views expressed by Dr. David Sinclair, A.O., Ph.D., are his own and do not represent those of Harvard University, Harvard Medical School, or any affiliated institutions.

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