The Adequacy of Rational Self-Interest in Morality

Is rational self-interest sufficient as a basis for morals and indeed all philosophy? What does Rand mean by rational self-interest? How must I decide what is rational? Is our rational self-interest often obvious? Is rational self-interest enforcable or at all self-enforcing? Is rational self-interest persuasive? Can it change the hearts of evil men, or at least lead them into less evil? Plus, taking potshots using Ayn Rand as ammo, and considering the context of the non-initiation-of-force principle.