I only follow about 70 people on Twitter or a lot more people follow me, but I find that I can manage just watching a small number of folks. Even if you're only following a low number like Dave mentioned 70, it isn't like Dave is reading every single tweet from all 70 of those people he's saying he does. That's why I keep my followers pretty low because those are people I'm actually really interested in what they're talking about. Instead of just the on-off switch of following people or not, I'm also beginning to curate what are called lists.