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Why does B12 damaged by nitrous oxide require megadosed folic acid rather than normal levels of folate? | Masterjohn Q&A Files #265
Mastering Nutrition
How to Make Methyl Groups From Folate
Five MTHF was the methyl donor for DNA and everything else? I think there's some confusion in terminology going on here, but let me share my screen and show you a couple. I'll show you folate metabolism first and then we'll take a look at that case report. All right. So folate's going from tetrahydropholate to dihydropholate after donating the CH2. It's reducing the CH2 to CH3. The answer to your question is that reaction is not a true methylation reaction. It's adding a methyl group in a two-step process of donating a methylene group and then reducing it to a methyl group. What we did
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