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The Protein Ribbon Folds the Way It Does
In theory, you can just observe the shape of the final folded structure. The most common way of doing this is by bombarding crystals of the protein with x rays and inferring its shape from the way that these beams are scattered. It can cost hundreds of thousands of dollars for each protein structure and take months or even years of work. max perrotts won a nobile prize in 19 62 just for figuring it out for one single protein, hemoglobin.