Pondering Cognitive Maps with Jim Knierim
Brain Ponderings podcast with Mark Mattson
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Alzheimer's Disease - Is There a Neurotransmitter in the Brain?
The lateral interonal cortex area in humans is one of the first areas to start showing the classic histological signal, the plaques and tangles that define Alzheimer's disease. In our rodent experience, what we found is that there are cells in the lateral front cortex that fire to objects as a rat explores the environment. And importantly, they encoded from the rats point of view, or it's called egocentric coding is what we would call it. This little pithy content versus context, lateral interrinal content, medial context, maybe the reason why there's these memory deficits.
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