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David Baker | De Novo Protein Design

Foresight Institute Radio

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Using Deep Learning to Build Proteins

Deep learning is infiltrating quickly, and so we are starting to use deep learning for both of these problems. The problem that we've really been focusing on for the last five or more years is the problem of building proteins completely from first principles. Even if you just use the 20 naturally occurring amino acids, there are for 100 residue protein, you have an astronomical number of possible sequences. There's this enormous space of possible proteins that evolution hasn't explored. We're trying to build proteins completely from scratch that are unrelated to any proteins of known structure.

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