Micro-Dosing and PAMs in Clinical Trials

This is an uncut interview recorded live at the 2022 Wonderland Conference in Miami, FL. Paul F. Austin is joined by renowned mycologist, author and researcher Paul Stamets, along with Pamela Kryskow, M.D., both co-founders of MycoMedica Life Sciences, PBC. They dive into all things microdosing, clinical trials, naturalistic science and patient-driven research, while exploring and honoring the wisdom of indigenous cultures around the world—and even martial arts.

Find episode links, summary, and transcript here.

Paul Stamets, speaker, author, mycologist, medical researcher and entrepreneur, is considered an intellectual and industry leader in fungi: habitat, medicinal use, and production. He lectures extensively to deepen the understanding and respect for the organisms that literally exist under every footstep taken on this path of life.

Paul’s philosophy is that “MycoDiversity is BioSecurity.” He sees the ancient Old Growth forests of the Pacific Northwest as a resource of incalculable value, especially in terms of its fungal genome. A dedicated hiker and explorer, his passion is to preserve and protect as many ancestral strains of mushrooms as possible from these pristine woodlands. His research is considered breakthrough by thought leaders for creating a paradigm shift for helping ecosystems worldwide.

Paul is the author of six books (including Mycelium Running: How Mushrooms Can Help Save the World, Growing Gourmet & Medicinal Mushrooms, and Psilocybin Mushrooms of the World). He has discovered and named several new species of psilocybin mushrooms.

Dr. Pamela Kryskow is a medical doctor with a strong interest in psychedelic medicine, mental health and chronic pain. She is a founding board member of the Canadian Psychedelic Association. She is also a part of an expert team working to give Canadians access to psilocybin at end of life.

Dr Kryskow is actively involved in research related to psilocybin, MDMA, ketamine, mental wellness and neurogenesis. She is a co-investigator on the largest microdosing study, Microdose.me, which is ongoing with 14 000+ enrolled participants.

A Clinical Instructor at University of British Columbia and Adjunct Professor at Vancouver Island University, Dr. Kryskow is also the medical lead on the Roots To Thrive Ketamine Assisted Therapy program, which treats healthcare providers with PTSD, depression, anxiety, and addiction. In real life, she loves foraging in the forest, ocean kayaking, growing kale and daydreaming in the hammock.

Highlights:

• An introduction to Paul and Pam, and their work together in researching the benefits of microdosing psilocybin.
• Tracking the history of mushroom wisdom and knowledge, from indigenous traditions to scientific research.
• How the complexity of microdosing demands new research approaches and methodologies.
• Addressing the disconnect between policy and science.
• Paul Stamets’ vision of how psychedelics can be integrated in society, and how MycoMedica is working towards it.
• How new scientific findings on psilocybin and microdosing could influence future legislation.
• Closing remarks: psychedelics, kindness, and community

Episode Links

• MycoMedica Life Sciences, PBC
• Microdose.me study
• Paul Stamets’ talk at the 2017 MAPS Psychedelic Science Conference
• The roots of ‘Two-Eyed Seeing’
• mushroomreferences.com
• Quantified Citizen App
• Paul Stamets’ Website
• Paul Stamets on Instagram
• Pamela Kryskow, M.D. on LinkedIn

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