The Effects of Wind Up on Pain Sensitization

Wind up is a marker of central sensitization. It can happen in particular when our nervous system and particularly when the central nerves kind of take on a little bit of a mind of their own. We think maybe these preoperative analgesics may help prevent some of that Well certainly if we're helping to spare opioids I know you know we get into other reasons of like well Why is it good to not necessarily give patients opioids? You know certainly side effects come into play all medicines have side effects But the more opioids people get the more likely they're gonna get side effects.