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#163 - Layne Norton, Ph.D.: Building muscle, losing fat, and the importance of resistance training

The Peter Attia Drive

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Hormonal Dynamics in Muscle Growth

This chapter explores the intricate relationships between testosterone, growth hormone, and muscle tissue, with a focus on androgen receptor density and its response to exogenous testosterone. It discusses the mechanisms of mechanotransduction and the role of hormones like IGF-1 in muscle growth, challenging misconceptions in bodybuilding about their anabolic effects. The chapter also delves into muscle contraction at the microscopic level, detailing the functions of sarcomeres and the influence of various hormones on muscle protein synthesis and breakdown.

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