Jacob Kimmel thinks he can find the transcription factors to reverse aging. We do a deep dive on why this might be plausible and why evolution hasnβt optimized for longevity. We also talk about why drug discovery has been getting exponentially harder, and what a new platform for biological understanding to speed up progress would look like. As a bonus, we get into the nitty gritty of gene delivery and Jacobβs controversial takes on CAR-T cells. For full disclosure, I am an angel investor in NewLimit. This did not impact my decision to interview Jacob, nor the questions I asked him.
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(00:00:00) β Three reasons evolution didnβt optimize for longevity
(00:12:07) β Why didn't humans evolve their own antibiotics?
(00:25:26) β De-aging cells via epigenetic reprogramming
(00:44:43) β Viral vectors and other delivery mechanisms
(01:06:22) β Synthetic transcription factors
(01:09:31) β Can virtual cells break Eroomβs Law?
(01:31:32) β Economic models for pharma
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