The Role of Neutrophils in Urinary Tract Infections

I put a lot of stock in the pyuria as to the other people who were writing the guideline and so let me just explain the rationale for that briefly. I was part of an international conference on urinary tract infections the first day was all basic science in the second day and sessions on clinical UTIs. Can you think of a way that E. coli could cause scarring of the kidney that does not go through neutrophilsYeah we've learned more about this process and realized that it's macrophages that set off the neutrophils but the final common pathway appears to be the pyureth  the neutrophils eating up the kidney causing this inflammatory response.