This chapter examines the various physiological challenges that astronauts face in microgravity, focusing on conditions like Spaceflight Associated Neuroocular Syndrome and the effects of fluid shifts on the body. It also highlights the importance of understanding the physiological differences between genders, bone density loss, and potential engineering solutions to enhance astronaut resilience against radiation and other space-related hazards. The discussion emphasizes the need for innovative approaches to maintain health and safety during long-duration space missions.

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