Exploring Epigenetic Signatures in Leiomyosarcoma Subtypes

Oncotarget’s cover paper this week (Volume 12, Issue 16) is entitled, "Epigenetic signatures differentiate uterine and soft tissue leiomyosarcoma," by researchers from Yale University School of Medicine, New Haven, CT. “In this study, we performed a comprehensive analysis and compared the DNA methylation and RNA expression profiles of ULMS and STLMS samples from the TCGA-SARC study.” First, the team identified two LMS subtypes based on their site of origin: uterine LMS (ULMS) and non-uterine soft tissue LMS (STLMS). Next, they compared their molecular landscapes using The Cancer Genome Atlas-Sarcoma (TCGA-SARC) dataset and comprehensively analyzed 27 ULMS and 53 STLMS samples. Researchers assessed for epigenetic and transcriptomic differences between ULMS and STLMS. They hoped these differences would help identify differentially methylated genes and differentially expressed genes (DEGs) in these LMS subtypes. Findings from the TCGA-SARC dataset were then compared to two independent DNA methylation datasets, GSE140686 and GSE68312. “In this study, we performed an integrated analysis of 98 clinically derived LMS samples and 11 controls using three publicly available datasets to identify epigenetic changes which characterize LMS subtypes and may be used as clinical biomarkers and therapeutic targets.” Datasets were then used in comparative DNA methylation analysis to compare controls with the identified epigenetic changes associated with tumorigenesis. Network and pathway analysis were performed to further characterize the differential transcription signatures between ULMS and STLMS. Full blog - https://www.oncotarget.org/2021/08/04/epigenetic-signatures-differentiate-leiomyosarcoma-subtypes/ Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28032 DOI - https://doi.org/10.18632/oncotarget.28032 Full text - https://www.oncotarget.com/article/28032/text/ Correspondence to - Nita Ahuja - nita.ahuja@yale.edu Keywords - leiomyosarcoma, epigenetics, DNA methylation, gene expression, uterine leiomyosarcoma About Oncotarget Oncotarget is a bi-weekly, peer-reviewed, open access biomedical journal covering research on all aspects of oncology. To learn more about Oncotarget, please visit https://www.oncotarget.com or connect with: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget YouTube - https://www.youtube.com/c/OncotargetYouTube/ LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Oncotarget is published by Impact Journals, LLC please visit https://www.ImpactJournals.com or connect with @ImpactJrnls Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957