Nostalgia, Growth, and AI Insights

This Week in Startups is brought to you by…

Northwest Registered Agent. Form your entire business identity in just 10 clicks and 10 minutes. Get more privacy, more options, and more done—visit https://www.northwestregisteredagent.com/twist today!

Lemon.io. Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist

Horatio. Visit https://www.hirehoratio.com/twist and get $2,000 off your initial set up.

Today’s show: Jason and Alex cover CoreWeave’s filing for a $35 billion IPO after explosive revenue growth. But with 77% of its revenue coming from just two customers, is it built to last? Meanwhile, AVRide is bringing autonomous Hyundai robotaxis to Uber in Dallas, pushing the self-driving revolution forward as Waymo scales to 200,000 weekly rides. And finally, Digg is back! Kevin Rose and Alexis Ohanian are reviving the iconic social news platform, using AI-powered moderation to tackle Reddit’s biggest challenge. Tune in as Jason and Alex break it all down!

Timestamps:

(0:00) Episode teaser(1:34) Jason's South by Southwest appearances & All In fan meetups(4:17) Digg relaunch, history, and Kevin Rose's AI strategy(10:05) Northwest Registered Agent. Form your entire business identity in just 10 clicks and 10 minutes. Get more privacy, more options, and more done—visit https://www.northwestregisteredagent.com/twist today!(11:43) Jason’s involvement with Digg’s revival and lessons learned(15:02) Using Reddit for startup communities(20:00) Lemon.io. Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist(22:07) Kevin Rose's journey and ketamine therapy(24:18) CoreWeave's public filing, clients, and revenue growth(29:52) Horatio. Visit https://www.hirehoratio.com/twist and get $2,000 off your initial set up.(34:22) CoreWeave's potential acquisition and investor IRR(40:45) Using LLMs for financial analysis and political funding discussion(46:19) CoreWeave data centers and AV Ride partnership with Uber(50:18) Challenges in electric bikes and healthcare startups(53:10) Novo Nordisk's direct-to-consumer strategy with Wegovy(57:28) Future of healthcare and Brian Johnson's health regimen(1:05:52) Challenges and excitement in the autonomous vehicle industry

Links from episode:

Check out digg: https://digg.com/

Check out AVRide: https://www.avride.ai/robot

Check out the Mozi app: https://www.mozi.app/

Check out Nerd Crawler: https://www.nerdcrawler.com/

Check out article about Novo Nordisk and Wegovy: https://www.cnbc.com/2025/03/05/novo-nordisk-goes-direct-to-consumer-with-wegovy-what-it-means-for-obesity-rival-eli-lilly.html

Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com

Check out the TWIST500: https://www.twist500.com

Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp

Follow Alex:

X: https://x.com/alex

LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm

Follow Jason:

X: https://twitter.com/Jason

LinkedIn: https://www.linkedin.com/in/jasoncalacanis

Thank you to our partners:

(10:05) Northwest Registered Agent. Form your entire business identity in just 10 clicks and 10 minutes. Get more privacy, more options, and more done—visit https://www.northwestregisteredagent.com/twist today!(20:00) Lemon.io. Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist(29:52) Horatio. Visit https://www.hirehoratio.com/twist and get $2,000 off your initial set up.

Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman

Check out Jason’s suite of newsletters: https://substack.com/@calacanis

Follow TWiST:

Twitter: https://twitter.com/TWiStartups

YouTube: https://www.youtube.com/thisweekin

Instagram: https://www.instagram.com/thisweekinstartups

TikTok: https://www.tiktok.com/@thisweekinstartups

Substack: https://twistartups.substack.com

Subscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916