Kelley's path to mitochondrial psychobiology

New research links chronic stress, brain energy, and psychiatric conditions, including PTSD, depression, and bipolar disorder.

Stress doesn’t just impact your mood; it affects how your brain allocates energy. In this interview, Dr. Bret Scher sits down with Dr. Parker Kelly, a postdoctoral fellow at UCSF and the San Francisco VA, to unpack the Allostatic Triage Model of Psychopathology, a new framework proposing that psychiatric symptoms may emerge when the brain is forced to triage limited metabolic resources under chronic stress. Co-authored with mitochondrial researcher Dr. Martin Picard, this model could shift how we understand and treat mental illness.

In this conversation, you’ll learn:

• How stress drives brain energy dysfunction
• Why mitochondria and metabolism may be central to mental illness
• Which brain networks are impacted by energy deficits
• The role of predictability and routine in stress resilience
• How metabolic therapies like nutrition, sleep, and even psychedelics, may support brain energy regulation

This conversation bridges neuroscience, metabolism, and mental health, offering a unique and unifying lens on complex psychiatric conditions.

👉Subscribe to Metabolic Mind for more conversations about metabolic health, metabolic psychiatry, and mental health: https://www.youtube.com/@metabolicmind.

#MetabolicMind #KetogenicTherapy #Neuroscience

Expert Featured:

D. Parker Kelley

• X.com/sequencemyneuro
• https://bsky.app/profile/sequencemyneuro.bsky.social
• https://www.linkedin.com/in/dparkerkelleyphd/

Resources Mentioned:

The allostatic triage model of psychopathology (ATP Model): How reallocation of brain energetic resources under stress elicits psychiatric symptoms

• https://doi.org/10.1016/j.neubiorev.2025.106419

Free CME Clinician Trainings:

Are you a clinician who would like to learn more about the science behind these therapies and how to implement them in practice? Earn CME with our growing library of courses from some of the top experts in the field including Dr. Chris Palmer, Dr. Georgia Ede, Dr. Matthew Bernstein and Dr. Bret Scher with more coming soon.

Our courses have been made FREE by grants from Baszucki Group, so we can spread these powerful therapies as widely as possible. Earn CME/CNE credits:

https://www.metabolicmind.org/for-clinicians/trainings-courses/?utm_medium=organic-social&utm_source=youtube&utm_campaign=cme-yt

Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.

Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/

About us:

Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.

Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.