Chlorthalidone and Blood Pressure

There are no fixed dose combinations with chlorthalidone. The VA cooperative trial didn't show any difference in terms of cardiovascular risk from hydrochlorothiazide versus chlorthidale. It's a long story, but I'll give you the short version-ish Chlorthodine is really hard to mix with other agents and it came out pretty late because it's an incredibly non-generic compound. So we don't have all the answers yet that sold us on this one.