Ibrutinib and MRD Negative Patients

The Captivate update was unique in that it looked at just the patients who had confirmed MRD negativity. And so about a little over half of the patients were randomized to Ibrutinib placebo. The unmutated IgHV again is starting to separate itself as time goes on, and these clones are going to grow back sooner. Those mutated patients are doing still very, very well regardless of their own placebo or IbrutInib. But you can see that maybe Ibrutsinib and continuation of treatment can really lock in this MRD negative state and they're going to do really, really well.