The Importance of Intrapation Variability

I want to start with the concept of variability. I think actually a slide you showed at ID week, a couple of years ago, really opened my eyes to this. You modeled 10 patients that all had the exact same crannin clearance and saw just a tremendous variation in their peaks and troughs. Can you tell us a little bit about that work and how that ties into this concept of intrapation variability? And then also while he has you, I want you to talk about something Joe mentioned with this, this aiming for four times the MIC. We talk about that a lot and I want to learn where that number came from. Yeah, absolutely. So hopefully we'll get into