Pre-Specification of Clinical Trials in Medicine

Stuart Buck is the Executive Director of the Good Science Project, a new initiative to make science funding more effective, innovative, and robust. This mission has been the major theme of Stuart’s career; he was previously Vice President of Research at Arnold Ventures, a large philanthropic foundation. In this conversation, we discuss the twin problems of reproducibility and innovation in science, and whether they’re in tension. We talk about whether and why most published research findings are false; how to fix career incentives in science; and why science should embrace red teaming, among many other things.

I recommend this essay by Stuart, which I reference during the conversation. The book I reference, The Enigma of Reason, is here and the review Stuart mentions is here.

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Thanks to Cofruition for consulting on and producing the show. You can learn more about Entrepreneur First at www.joinef.com and subscribe to my weekly newsletter at tib.matthewclifford.com