The Extreme Cases of Monogenic Longevity Genes

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Mice that have lost both copies of genes in pituitary pathways can live an extraordinarily long life. They are infertile, they can't maintain their body temperature and even if they could attract mates, they couldn't produce sperm or egg. The mice would be bullied to death if they were kept in cages with their brothers and sisters that didn't have defective copies of the particular genes.

Episode #272. In the quest for an extended lifespan, has science been led astray? Join me as I sit down with Professor Charles Brenner, a leading global expert in NAD biology, to examine the longevity field's claims and controversies.

From debunking common beliefs to questioning high-profile opinions, Dr Brenner delivers a refreshingly candid perspective on the science of aging. Tune in to explore why he believes there's no “cure” for aging, the limitations of animal studies, and what the future might hold for this complex field.

Specifically, we discuss:

Intro (00:00)
Do we have the genes to live beyond 120 years? (3:54)
The genetics of extreme longevity (14:18)
Longevity in the animal kingdom (18:26)
Why do we age, and the realities of extending lifespan (31:22)
How long can we live? (39:01)
NAD coenzymes and DNA repair (43:49)
"Anti-ageing" products (55:17)
Conflicts of interest and the integrity of scientific claims (1:01:08)
Discovering nicotinamide riboside (NR) (vitamin B3) (1:03:19)
Sirtuins as anti-ageing genes (1:09:22)
A rebuttal to Drs. David Sinclair and Lenny Guarente (1:19:13)
Seeking consensus on the study of human longevity (1:32:57)
The information theory of aging (1:43:19)
Dr. Charles Brenner's theory of ageing (2:00:28)
How to age better (2:03:30)
Dr. Brenner on the quality of life (2:09:05)
NR supplementation (2:10:09)
Moving beyond Yamanaka factors (2:15:02)
Outro (2:18:45)

Connect with Dr Charles Brenner on Twitter, and visit his website, https://www.brennerlab.net/, for more.

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Enjoy, friends.

Simon

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Simon Hill, MSc, BSc (Hons)

Creator of theproof.com and host of The Proof with Simon Hill

Author of The Proof is in the Plants

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