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Building the DNA Oracle with Eeshit Vaishnav

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How Do You Model Stabilizing Selection?

Roxanne Jones: I was wondering if you could dive a little bit deeper into how you did this modeling work like you have these various different evolutionary regimes. How are you imposing the constraints on your model and how you doing it across multiple generations to start with a set of sequences? Let's say start with 10,000 random sequences. You predict the expression for each of these 10,000random sequences. And then the next step is what varies across these four regimes. For each regime, you would pick a sequence for the next generation corresponding to each of those 10,000 starting sequences.

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