When you ask everybody to try to get lucky in a systematic way, the odds of that happening are going to be much, much higher. And so i think if you say, we're gongto take all the people with crone's disease, and we want o experiment, and everybody get back with us,  it'll either work or it won't. If it works, great, it confirms a model. If it doesn't work, then you put that back into the model. Because there's something unique about you that made you slightly different than the other folks who have had success. It's crazy, but yet, i think that is sort of the the balance of