#75 – Breakpoints Talks Breakpoints: Aminoglycosides
Breakpoints
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Aminoglycosides as Monotherapy for Urinary Tract Infections
The only real clinical PKPD target that we really have is maximum concentration over MIC. And with the old breakpoints, there was just no way to get Tobar-Mison exposures that had a C-Max over MIC of eight or 10 without lowering the breakpoint. So those were the changes. We can certainly get into the nitty gritty of why we went there. But this was one of those clear examples where the microdata was telling us one thing, the PKPD data were telling us something else.
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