Antidepressents - What's an Adequate Trial?

Some people make it into these studies with an undiagnosed or heretofore diagnose by polar disorder, and they've failed prosa. An adequate trial would be based on adequate dose for at least, let's say, six or eight weeks on that medicine. We want to rule out the big things, like is there a substance ab sproblem that's actually co occurring with their depression? And then within the realm of psychiatryo psychiatric diagnoses, there's psychotic type depressions which are treated.