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Chapter Eleven, part 1: Regulation of Acid-Base Balance

Channel Your Enthusiasm

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How the Distal Nephron Sensitizes Blood pH?

There are lots of different ways to sense pH. There are pH sensitive ion channels that lead to ion currents into the distal nephron, the tubule cells. hydrogen ion sensitive G protein coupled receptors that sense the hydrogen ion changes, the pH changes. kinases and enzymes whose activity increases or decreases depending on the pH as well. And so some combination of all these mechanisms seems to be the upstream stuff that leads to downstream insertion of these hydrogen ATPase pumps into the membrane.

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