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IBCC Episode 112 - Valproic Acid Toxicity

The Internet Book of Critical Care Podcast

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Introduction

This is particularly important for patients you took sustained release or extended release valprok acid. Over about a hundred, 50 m g per m l, it's increasingly free. This can essentially cause what is known as the so called toxin bomb. The liver basically sticks clucronic acid onto it, stuffs it into the bile and it gets excreted.

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