Matt Walker welcomes Dr. Ranji Varghese to the podcast this week for an in-depth conversation about sleep and prescription sleeping pills. A psychiatrist specializing in sleep medicine, Dr. Varghese begins by discussing his entry into the field which was sparked by a fascination with sleep and wake circadian rhythms. He goes on to highlight the Minnesota Regional Sleep Disorder Center's focus on parasomnias, particularly REM Sleep Behavior Disorder, emphasizing the intersection of neuroscience, physiology, and psychology in sleep medicine.
As you will hear, sleeping pills, prescribed to initiate or maintain sleep, are typically used as a last resort for insomnia after other treatments fail. Dr. Varghese explains they work by modulating brain activity, often targeting neurotransmitters like GABA or melatonin receptors. He details two main classes: benzodiazepines (like Restoril and Ativan) and non-benzodiazepines (Z-drugs like Ambien and Lunesta), outlining their mechanisms, benefits, and risks. His powerful personal anecdote and the discussion of complex sleep-related behaviors underscore the critical need for careful consideration and informed decision-making when using these medications.
Please note that Matt is not a medical doctor, and none of the content in this podcast should be considered medical advice in any way, shape, or form, nor prescriptive in any way.
Long-time show sponsor LMNT is Matt Walker’s go-to for a sugar-free electrolyte mix. With the perfect electrolyte balance and science-backed formulation, LMNT is a product Matt trusts daily, adding it to his workouts and protein shakes. And now, for a seasonal twist, their Chocolate Medley range is back with flavors like Chocolate Mint and Matt’s favorite, Chocolate Raspberry. Get a free sample pack with any purchase at drinklmnt.com/mattwalker—just use his link to try it yourself!
Another great sponsor of the show is AG1, a comprehensive nutritional drink trusted by thousands worldwide, including Matt! For nearly four years and counting, he has relied on AG1 to fuel his post-workout routine with its powerhouse blend of over 75 essential minerals, vitamins, probiotics, and prebiotics, meticulously crafted to support your daily nutritional needs. AG1 is registered and approved by the Therapeutic Goods Administration, boasting GMP badges for quality assurance. As a special offer for our listeners, when you try AG1, you'll receive a complimentary one-year supply of both Vitamin D and K2, and with your first subscription, you'll also receive five free AG1 travel packs! Visit AG1 to explore AG1's range of offerings and claim your exclusive offer.
As always, if you have thoughts or feedback you’d like to share, please reach out to Matt on Instagram.
Matt: Instagram @drmattwalker or on X @sleepdiplomat
Connect with Dr. Varghese:
Instagram: @docvarghese
X: @docvarghese
Minnesota Regional Sleep Disorders Center:
https://www.hennepinhealthcare.org/specialty/minnesota-regional-sleep-disorders-center/
IIT-MN: https://iit-mn.com/
