Navigating Hormonal Complexity

What if the most powerful upgrades for brain energy, metabolism, and drive aren’t in mainstream medicine, but in rare peptides and misunderstood hormones? In this episode, you’ll discover the cutting-edge compounds, nootropics, and hormonal strategies that elite biohackers are using right now to optimize every part of their biology. 

Watch this episode on YouTube for the full video experience: 

https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with Jay Campbell and Hunter Williams, co-founders of BioLongevity Labs—a performance biotech company creating oral peptide-based products like BioMind and BioGutPro. Jay is a globally recognized expert in testosterone optimization, author of The TOT Bible, and a leading voice in hormone and peptide therapeutics. Hunter is a high-performance coach and podcast host focused on metabolism, mindset, and men’s health through functional medicine and advanced supplementation. 

In this high-energy, high-clarity conversation, the trio explore what’s working right now in advanced human performance, spanning hormone synergy, mitochondrial enhancement, libido compounds, nootropics, and muscle-preserving stacks. You’ll hear why Dave injects estradiol three times per week, how Jay and Hunter use oral bioregulators to improve gut-brain signaling, and what peptides are quietly reshaping the future of health. 

 You’ll Learn: 

• Who should use estradiol—and how it can protect brain performance in men 

• The real role of testosterone and estradiol synergy in male health and longevity 

• How BioLongevity Labs is innovating with oral peptide delivery for cognitive and gut health 

• Why peptides like BPC‑157, TB‑500, PT‑141, and SS‑31 are changing mitochondrial care 

• The truth about Melanotan‑1, SLU, AOD‑9604, GW‑501516, and BAM‑15 

• What makes BioMind and BioGutPro different from standard nootropic or probiotic stacks 

• Why libido and metabolic health are deeply connected 

• The dangers of unvetted peptide sources—and what to look for in quality and bioavailability 

This is essential listening for anyone serious about biohacking, hormone optimization, mitochondrial support, brain energy, nootropics, neuroplasticity, functional medicine, sleep optimization, metabolism, and smarter-not-harder living. 

Keyword Index: 

estradiol for men, Dave Asprey hormone therapy, Jay Campbell BioLongevity Labs, Hunter Williams performance coaching, BPC‑157 recovery peptide, TB‑500 tissue regeneration, PT‑141 libido peptide, SS‑31 mitochondria peptide, Melanotan‑1 for skin and mitochondria, SLU stack, AOD‑9604 fat loss peptide, GW‑501516 Cardarine, BAM‑15 mitochondrial uncoupler, oral peptide delivery, BioMind brain supplement, BioGutPro gut-brain axis, testosterone estradiol synergy, mitochondrial uncoupling, nootropic peptide stacks, performance biohacking supplements 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. 

Episodes are released every Tuesday, Thursday, and Friday where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. 

 Thank you to our sponsors!  

• Puori | Head to http://puori.com/dave for 20% off, including subscriptions.  
• Leela Quantum Tech | Head to https://leelaq.com/DAVE for 10% off.  
• ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. 

 Resources:  

• BioLongevity Labs Website: https://biolongevitylabs.com/?ref=DAVE# 

• Dave Asprey’s Website: https://daveasprey.com 

• Danger Coffee: https://dangercoffee.com/DAVE15 

• Dave Asprey’s BEYOND Conference: https://beyondconference.com 

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated 

• Upgrade Collective: https://www.ourupgradecollective.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen: https://40yearsofzen.com 

Timestamps: 

00:00 – Trailer 

01:00 – Introduction & Early Days of Biohacking 

02:03 – Peptides 101: Foundations and Frameworks 

03:06 – Peptides for Healing, Cognition, and Longevity 

07:56 – Bioregulators and Russian Innovations 

11:07 – Side Effects and Safety of Peptides 

22:27 – Oral Peptides and Product Innovations 

27:41 – Body Composition, Hormones, and Fat Loss 

32:02 – Testosterone, Estrogen, and Male Health Protocols 

45:03 – Peptides for Performance, Fat Loss, and Longevity 

1:26:32 – Loose Skin, Surgery, and Body Transformation 

1:38:00 – Closing Thoughts & Product Recommendations 

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