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The Influence of Saponins on Gut Permeability and Active Nutrient Transport
Saponins are defense chemicals that irritate the human gut and cause activation of the immune system. They may even bind the TLR4 or TLR5 receptors, toll-like receptors in the gut,. leading to inflammation, cascades downstream, increasing things like cortisol, serotonin, or estrogen. Most human illness begins in the gut; there's not much of a way to avoid these saponins other than placing them in your oats where they can be easily disposed of.