The Influence of Saponins on Gut Permeability and Active Nutrient Transport

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Saponins are defense chemicals that irritate the human gut and cause activation of the immune system. They may even bind the TLR4 or TLR5 receptors, toll-like receptors in the gut,. leading to inflammation, cascades downstream, increasing things like cortisol, serotonin, or estrogen. Most human illness begins in the gut; there's not much of a way to avoid these saponins other than placing them in your oats where they can be easily disposed of.

Have you been led to believe that oatmeal is good for you? This podcast is for you! Paul does a deep dive on why you may want to cut oats (and chocolate, and leafy greens) out for good for reasons like heavy metal accumulation, antinutrients, and defense chemicals.

00:07:30 The problem with grains

00:11:45 Heavy metals in oats, greens, chocolate and fish

00:20:00 How saponins damage the gut

00:31:30 Cadmium and heavy metals in oats, vegetables and chocolate

00:48:15 Phytic acid

00:49:20 Pesticides in your oats

00:50:50 Mold contamination in grains

00:53:00 Takeaways on oats

References:

Influence of saponins on gut permeability and active nutrient transport in vitro: https://www.semanticscholar.org/paper/Influence-of-saponins-on-gut-permeability-and-in-Johnson-Gee/b100e152961fa3beb84c676ac0ae43e74b52af9e

Reducing the damage of quinoa saponins on human gastric mucosal cells by a heating process: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977518/

Triterpenoid Saponins in Oat Bran and Their Levels in Commercial Oat Products: https://figshare.com/collections/Triterpenoid_Saponins_in_Oat_Bran_and_Their_Levels_in_Commercial_Oat_Products/5002223

The biological action of saponins in animal systems: a review: https://pubmed.ncbi.nlm.nih.gov/12493081/

Effect of oat saponins and different types of dietary fibre on the digestion of carbohydrates: https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/effect-of-oat-saponins-and-different-types-of-dietary-fibre-on-the-digestion-of-carbohydrates/95992869AEC98CFAB161548C043F93E7

Effects of saponins and glycoalkaloids on the permeability and viability of mammalian intestinal cells and on the integrity of tissue preparations in vitro: https://pubmed.ncbi.nlm.nih.gov/20650190/

A major gene for grain cadmium accumulation in oat (Avena sativa L.): https://www.researchgate.net/publication/6204970_A_major_gene_for_grain_cadmium_accumulation_in_oat_Avena_sativa_L

Toxicity of cadmium and its health risks from leafy vegetable consumption:https://www.researchgate.net/publication/313975727_Toxicity_of_cadmium_and_its_health_risks_from_leafy_vegetable_consumption

Ideal Cereals With Lower Arsenic and Cadmium by Accurately Enhancing Vacuolar Sequestration Capacity: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467212/

Cadmium Levels in Soils and Crops in the United States: https://www.semanticscholar.org/paper/Cadmium-Levels-in-Soils-and-Crops-in-the-United-Chang-El-Amamy/18c4415de7340ae4b30ac9516c1acae4c4ed6300

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