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We Shih Tzu Not, Hypoallergenic Pets Aren't A Thing.

Unbiased Science

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The Effects of Pet Allergies on the Mast Cell

The mast cell is the most important. So I would say with the allergic reaction, basal cells are also sometimes involved. And histamine is already kind of preformed. It's already inside the cell. As soon as the mast cell degranulates or opens, burst opens and releases the histamine, the reactions are immediate. That's why people know it can be instant within seconds to minutes.

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