Too much insolent causes an resistance. But then there are two other inputs that i consider to be primary causes. I consider them to be primary because, once again, in cells, rodents and humans,. The literature supports this idea. One of them is stress. We know that sleep deprivation will increase those stress hormons. A bad night of sleep will create insolent resistance the next day. Inflammation if we just activate inflammatory pathways independent of stress, like cortesal, independent of insolent itself, we can cause insolent resistances. And so with inflammation, you see in people with auto immune diseases, where they have, as the auto immunity is active, so too is

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