Ep 180 Acetaminophen Poisoning – Pitfalls in Assessment and Management
Emergency Medicine Cases
What Is a Massive Overdose?
The massive overdose patient is something that I like to think of is actually a very distinct toxidrome from what we've been speaking about earlier. The patients that I'm concerned about who take a massive overdose, Margaret's given us a 500-meg per kilo, for example, may fit this toxidrome. And the acetaminophen parent compound and the NACCHE as well are interacting with one of the enzymes in oxidative phosphorylation and our electron transport chain. It affects the way energy is being produced in our cell.
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