This chapter examines the intricacies of causal inference methods for emulating clinical trials through real-world evidence. It contrasts propensity score matching with other techniques while addressing challenges like informative censoring, ultimately highlighting its benefits in delivering interpretable results for regulatory preferences.
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Keynote by Prof. Sebastian Schneeweiss | The Effective Statistician Conference 2024
What You’ll Learn:
✔ The motivation behind emulating randomized trials using real-world data
✔ How claims and EHR data can support regulatory-grade evidence
✔ What makes a trial emulation good vs. suboptimal
✔ The role of adherence, measurement limitations, and data quality
✔ Use cases where RWE could expand indications or replace costly trials
✔ Key takeaways from the RCT DUPLICATE project and the “Benchmark-Calibrate-Extrapolate” strategy
Recommended For:
✔ Biostatisticians and epidemiologists
✔ Health tech innovators and data scientists
✔ Regulatory affairs and clinical development professionals
✔ Anyone involved in real-world data, RWE, or comparative effectiveness research
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If you’re working on evidence generation plans or preparing for joint clinical advice, this episode is packed with insights you don’t want to miss.
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