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TWiV 954: Speculating sarbecovirus spillovers with Michael Letko

This Week in Virology

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The Cost of Clay 3 Viruses

The Clay 3 viruses have one deletion and they're missing a lot of the contact. The amino acids that we find in the viruses that use our combined humanase too are not conserved in a lot of them. These were found in horseshoe bats, did you say?These were found in... Yeah. All right. So because the interface is just different enough from the bat side, the virus doesn't have mutations that can compatible.

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