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The Endline of Weapon Systems
On a long enough time scale, i can take a synthetic biology lab in my room and create a weaponized virus that combines the most virulent features of small pox and the longevity of aids. I think commercial air travel will come to an end because weaponized drones will be prevalent. Even if nobody has any malicious intent, little johnny cond could create a singularity as part of his high school physics experiment by accident. It's much easier to destroy something with a nuclear weapon than it is to build a nuclear power plant.