How Testosterone Replacement Therapy Affects the Testosterone Receptor

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GNRH tells the pituitary to make LH and FSH. They tell the testes to make testosterone. Small amounts of that are siphoned off to make DHT. And even smaller amounts, i.e. less than 1%, are siphoning off to make estrogen. The system is in perfect balance. But it's not as simple as looking at the total testosterone or even the free testosterone.

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In this special episode of The Drive, Peter provides a comprehensive overview of the various endocrine systems: the thyroid system, the adrenal system, and the sex hormone system (for both men and women). He walks through the basic biology and the feedback cycles that regulate the production of these hormones and discusses the various options for the treatment of hormone deficiencies. In addition, Peter delves into hormone replacement therapy (HRT), providing nuanced insights into its appropriate usage and the clinical approach he adopts when working with patients.

Peter supplements these explanations with whiteboard illustrations. For a more complete understanding, we highly recommend watching these videos over just listening. The videos can be found on our YouTube channel or on the show notes page.

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