Introduction

Dr. Richard Miller runs one of the labs for the Interventions Testing Program or the ITP, which is largely considered the gold standard for testing longevity drugs. This was one of the best conversations I’ve had on longevity supplements that affect lifespan and those that might me subject to mere hype. Dr. Miller is rigorous in his approach and states the data clearly. He also has opinions on lifespan vs. healthspan that are unique from those of most others and worth paying attention to. I genuinely walked away having learned so much from this conversation and feeling more awakened, and I hope it is useful to you too in parsing the data out there on longevity supplements.  

In today’s episode, you will learn: 

- The 4 winning drugs that increase lifespan in mice as tested by the ITP: Rapamycin, Acarbose, 17-alpha estradiol, Canagliflozin 

- 3 other drugs that produce small lifespan benefits: NDGA, Glycine, Captopril 

- Drug combinations: Rapamycin + Acarbose, Rapamycin + Metformin 

- Drugs that show no lifespan increase in mice in the ITP: Resveratrol, Nicotinamide-Riboside (NR), Fisetin, Curcumin, MCT Oil, Green tea extract, Fish Oil + more 

- Richard’s thoughts on lifespan vs. healthspan  

All platforms / Episode Show Notes / Timestamps: https://livelongerworld.substack.com/p/rmiller 

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RICHARD MILLER LINKS: 

Website: http://www.richmillerlab.com/

Photography: https://richardmiller.zenfolio.com/

Interventions Testing Program: https://www.nia.nih.gov/research/dab/interventions-testing-program-itp 

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TIMESTAMPS: 

0:55 Richard Miller Intro 

1:51 Richard Miller Wildlife photography 

3:30 ITP - the gold standard for testing longevity drugs & winning drugs 

10:51 Rapamycin, Rapamycin + Acarbose 

18:48 Rapamycin + Acarbose Dosing Schedule 

20:15 Combination of drugs, Rapamycin + Metformin 

21:56 17-Alpha Estradiol 

25:45 Canagaflozin 

31:34 Does Richard take the 4 winning drugs? 

32:46 3 Drugs that have small lifespan effects & promising 

36:30 GPLD-1 & shared mechanisms in longevity drugs 

44:04 Resveratrol in ITP 

46:27 NR, NMN 

52:34 Curcumin, Green Tea Extract, MCT Oil 

54:54 Fisetin & Senolytics 

56:12 Why most published research findings are false 

1:00:03 Healthspan biomarkers at the ITP 

1:02:38 Can you have healthspan without lifespan? 

1:07:37 Fish Oil, Spermidine, Sulforophane 

1:12:13 Unpublished data Richard is excited about 

1:17:47 Flying Pigs & Aubrey De Grey 

1:20:00 Exponential rise in aging research

Episode Show Notes: https://livelongerworld.substack.com/p/rmiller

Thanks for listening & if you enjoy the episode, let's spread the message on longevity. You can leave a review on Apple podcasts, subscribe and share the podcast. 

Aging is universal. Let's unite in this fight.