The Importance of Calorie Restrictions

P53 is the key tumor suppressor. It gets fed signals from above, which say, hang on, we've got something bad happening here. Then it calls in a whole lot of other genes and if there's something messed up with the network below or the network feeding into it, then you can get cancer. If P53 is doing its job, absolutely right, you shouldn't be able to get cancer. But there's all kinds of things in the network that can go wrong and stop P53 doing things right. And so how does that relate to, I think you remember you talking about P21 and all these other sort of genes. How does that relate? No, well

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