The Importance of Calorie Restrictions

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P53 is the key tumor suppressor. It gets fed signals from above, which say, hang on, we've got something bad happening here. Then it calls in a whole lot of other genes and if there's something messed up with the network below or the network feeding into it, then you can get cancer. If P53 is doing its job, absolutely right, you shouldn't be able to get cancer. But there's all kinds of things in the network that can go wrong and stop P53 doing things right. And so how does that relate to, I think you remember you talking about P21 and all these other sort of genes. How does that relate? No, well

Why should we stop ageing? Today we talk about everything to with ageing, why it occurs, why there’s renewed interest in it and what we can do about it. Sue beautifully lays out the history of longevity research, the origins of this fascinating scientific discipline and what the latest research means for you.

We’re taking a short break on the podcast this week so we’re diving into the rich archives of The Doctor’s Kitchen Podcast to resurface one of my favourite conversations from 2 years ago.

Sue Armstrong is a writer and broadcaster specialising in science, health and development issues and author of one of my favourite books on longevity, “Borrowed Time – The science of how and why we age”.

Today we discuss how Sue's career got started as well as her experience reporting on Nelson Mandela’s release from prison as well as her time spent researching HIV.

We talk about:

The origins of ageing research

The different theories of why we age

Cellular senescence

The ageing immune system

Calorie restriction and its pros and cons

And lots more

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