with @matthewclifford @smc90

This special episode is all about regional innovation — at both a systems and people level.

We cover what does and doesn’t work in making certain places become hubs of innovation and economic growth (aka “innovation ecosystems”). But we also discuss — going back and forth between the structural and individual — when to intervene for entrepreneurial talent; the nature of ambition, yearning, and finding one’s path; and more broadly, mindsets for navigating risk/reward and dynamism in different regions including London and Europe. We also discuss new ways of funding breakthrough R&D at a national level, tech trends of interest including crypto, and much more.

Our special guest — in conversation with editor in chief Sonal Chokshi, who also brought him to the a16z Podcast over 8 years ago in its first-ever UK roadshow in December 2015 — is Matt Clifford, who’s played an important role in the London entrepreneurial and tech ecosystem since 2011. Matt is the Chair of Entrepreneur First (which he co-founded with Alice Bentinck over a decade ago); and is also the Chair of the UK’s Advanced Research and Invention Agency (ARIA). [Before this episode was recorded, Matt was also the Prime Minister’s representative for the AI Safety Summit — which he helped organize at Bletchley Park (the historic home of computing in the UK); after this episode was recorded, Matt was appointed by the UK secretary of science to deliver an “AI Opportunities Action Plan” to the UK government, which was just announced last week.]

Fittingly, this episode was recorded live from Andreessen Horowitz’s first international office, in London; for more on our efforts there, and other content from there, please visit a16zcrypto.com/uk.

As a reminder: None of the following should be taken as investment, legal, business, or tax advice; please see a16z.com/disclosures for more important information -- including a link to a list of our investments.