Episode 126: Depression and Serotonin
The Science of Everything Podcast
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Serotonin and Brain Derivative Neurotrophic Factor in Depression
Depression has been linked to changes in the structure and function of various brain regions compared to healthy controls. Many of these regions are part of what's called the corticolymbic system, so this includes the amygdala and hippocampus and parts of the cortex. This is involved in processing emotional responses and helps to regulate the top-down feedback that's received from other areas of the cerebral cortex. So it appears that patients with depression have a reduced capacity for both neurogenesis, a production of new neurons as well as reduced capacity for neuroplasticity.
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