Sleep, glymphatic clearance, and sedative risks

Dr. Sahil Chopra joins Dr. Jeff Graham to discuss sleep as a core driver of cardiometabolic health, cognitive performance, and long-term longevity. They break down how acute and chronic sleep deprivation affect physiology differently, why conditions like insomnia and obstructive sleep apnea are often missed, and how sleep disruption increases risk for cardiovascular disease, metabolic dysfunction, and neurodegeneration. The conversation also explores what "healthy sleep" actually looks like from a physiologic standpoint, the limits of consumer wearables, and how detailed sleep assessment can guide more precise, individualized care over time.