• Why stress is not your friend
  

• The effects of cortisol on your mitochondria

• Hans Selye’s general adaptation syndrome

• How cortisol causes mitochondrial dysfunction, heart disease, insulin resistance, autoimmunity, allergies & hypersensitivity, mineral imbalances, and cancer metabolism

• Why acute stress does not lead to improved health via hormesis

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Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-93-how-cortisol-affects-your-mitochondria-acute-vs-chronic-stress-stress-mitochondria-part-1-ep-93/ 

Timestamps:

3:00 – an introduction to the paper: mitochondria as key components of the stress response   

4:03 – Hans Selye’s general adaptation syndrome and the process of stress in relation to energy balance  

23:30 – the 3 main effects of the stress hormones in the acute stress response and the cost to this response 

31:48 – long-term glucocorticoid exposure causes insulin resistance and the protective effects of high blood sugar in certain contexts 

34:04 – how long-term stress causes degeneration 

34:55 – functions of the mitochondria 

38:54 – mitochondria upregulate energy production in response to stress 

41:06 – the short-term vs. long-term effects of the glucocorticoids (cortisol)

44:03 – how stress causes hormetic adaptations and how the hormetic pathways cause degeneration over time

50:30 – how mitochondria respond to excess stress and how this relates to fat gain

59:04 – how chronic stress and exposure to cortisol causes impaired energy production, degeneration, immunosuppression & autoimmunity, mineral imbalance, swelling, allergies & hypersensitivity, and cancer metabolism