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Ep. 59: “Infectious Disease Ecology and Evolution” Featuring Dr. Daniel Streicker

The Immunology Podcast

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Exploring T-cell Specificity in Cancer Immunotherapy

The chapter delves into a study investigating T-cell receptors' specificity in identifying tumor-associated antigens during cancer immunotherapy. It discusses a patient's remission after treatment with tumor-infiltrating lymphocytes and the discovery of a T-cell clone recognizing multiple tumor antigens, leading to insights on potential multi-pronged targeting strategies. The episode also explores a novel finding about T cells targeting multiple antigens simultaneously, highlighting implications for cancer therapy and the patenting of such discoveries.

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