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Universal Flue Vaccine
A universal flue vaccine would also, hopefully be good for multiple years. The current vaccine is only ten to 60 % effective, depending on the year. A former dean of the harvard school of public health and a former president of the national academy of medicine thinks it would cost just one 200 million dollars to fund a fully dedicated effort. He points off that even if he's off by an order of magnitude and it cost one to two billion dollars total, it's a staggeringly good deal.