CRISPR, Ethical Risks, and Off‑Target Effects

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Dr. Melissa Ilardo, Ph.D is a professor of evolutionary genomics and biomedical informatics at the University of Utah. Her research explores human evolution and adaptation in populations that have previously been overlooked or excluded from biological research. Her recent work looks into a population who engages in the practice of breath-hold diving & is evolving on a unique breakaway trajectory from the rest of homo sapiens on earth.

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EPISODE LINKS

https://medicine.utah.edu/faculty/melissa-ilardo

https://www.superhumanlab.org

https://www.nytimes.com/2018/04/19/science/bajau-evolution-ocean-diving.html

https://www.instagram.com/superhumanscilab

https://linkedin.com/in/melissa-ilardo

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OUTLINE

00:00 - Genomic evolution of Baju people (sea nomads)

15:00 - How long Baju can hold their breath for

21:19 - All-female Korean free divers (Haenyeo)

32:17 - Lost species of humans

42:44 - Humans won't survive the next 100,000 years

47:50 - Mother of humanity: The real "Eve"

59:48 - Humans are attracted to mates by pheromones

01:06:30 - Why assisted reproductive technology might be harmful to evolution

01:14:57 - Effects of the global population mixing & mating together

01:21:37 - Risks of CRISPR gene editing

01:30:37 - Lifespan & the grandmother hypothesis

01:37:18 - Evolution of un-contacted indigenous tribes

01:40:50 - What future humans will look like

01:49:08 - Intelligence is not genetic

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